Image 1 of 1: ‘image showing humans and mice along with neuroimaging, neuropathology, and heatmap images representing the different modalities to align.’
Aligning Human and Mouse Phenotypes
Figure 2
Image 1 of 1: ‘list of AD phenotypes associated with 5xFAD mouse model’
5xFAD Mouse Phenotypes
Figure 3
Image 1 of 1: ‘table showing AMP-AD studies, the number of samples, and brain regions sampled’
Transcriptomic studies of Alzheimer’s
Disease
Figure 4
Image 1 of 1: ‘Heatmap showing the overlap between co-expression clusters and the consensus clusters.’
AMP-AD GENE Modules
Figure 5
Image 1 of 1: ‘Example correlation plots for AMP-AD co-expression module genes and mouse model expression.’
Human-Mouse logFC correlation
Figure 6
Image 1 of 1: ‘Figure showing different methods to test functional enrichment.’
Functional enrichment approaches
Figure 7
Image 1 of 1: ‘Figure from the paper showing the number of papers examined that failed to meet certain standards for reporting the results of functional enrichment testing.’
Common pitfalls
Figure 8
Image 1 of 1: ‘An image of a brain surrounded by different endophenotype categories that are associated with AD.’
Endophenotypes of AD
Figure 9
Image 1 of 1: ‘Circle plot showing therapeutics in various stages of clinical trials coded by the CADRO target class.’
Common AD Research Ontology
Figure 10
Image 1 of 1: ‘Bar plot showing the numbers of agents in clinical trials across each class.’
Drugs in Pipeline by CADRO
Figure 11
Image 1 of 1: ‘Heatmaps showing the fraction of overlapping GO terms and genes between the various biological domains.’
AD Biodomain Demographics
Figure 12
Image 1 of 1: ‘Plot showing the number of subdomains associated with each domain and how many GO terms are assigned to each domain.’
