Introduction to Omics Translation in AD
Synapse and AD Knowledge Portal
Differential expression analysisDifferential Expression Analysis
Cross Species Functional Alignment
- AMP-AD gene modules represent major transcriptomic heterogeneity in AD
- Correlation of logFC is a practical approach for human-mouse alignment of AD-associated transcriptomic signatures
- Functional gene set signatures are also a useful point of comparison between species
- Subsetting functions into associated Biological Domains and Subdomains allows for more granular comparisons
Choosing the right animal modelsWan et al mouse model compendium
- AD is complex and human patient populations are heterogenous
- Molecular subtyping is one way to reduce that complexity
- We can use identified human subtypes to help characterize mouse models
- Each existing mouse model of AD may match to a particular subset of human AD subtypes but not all subtypes simultaneously.
- Most of the molecular AD subtypes were identified using transcriptomics data and there seems to be similarities between AD subtypes across studies.