Introduction to Omics Translation in AD

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Synapse and AD Knowledge Portal

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• Use your Synapse login credentials to access the Portal.
• Use Synapser package to download data from the Portal.

Differential expression analysisDifferential Expression Analysis

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• Use your Synapse login credentials to access the Portal.
• Use Synapser package to download data from the Portal.

Mouse human alignment of transcriptomic signatures

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• AMP-AD gene modules represent major transcriptomic heterogeneity in AD
• Correlation of logFC is a practical approach for human-mouse alignment of AD-associated transcriptomic signatures
• Functional gene set signatures are also a useful point of comparison between species
• Subsetting functions into associated Biological Domains allows for more granular comparisons.