Glossary

Key Points

Introduction
Synapse and AD Knowledge Portal	Use your Synapse login credentials to access the Portal. Use Synapser package to download data from the Portal.
Differential Expression Analysis	Validate metadata prior to data analysis. Use function for repeated differential expression analysis in multiple comparisons.
Mouse-human alignment of transcriptomic signatures	AMP-AD gene modules represent major transcriptomic heterogeneity in AD. Correlation of logFC is a practical approach for human-mouse alignment of AD-associated transcriptomic signatures.
Functional Alignment using AD Biological Domains	Functional signatures are a useful point of comparison between species. Subsetting functions into associated Biological Domains allows for more granular comparisons.

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